Quick answer: White on pothos leaves can be a normal cultivar trait or a sign of bleaching and injury. First identify the plant: Marble Queen and Pearls and Jade naturally carry pale patterns, while ordinary green pothos leaves developing dry white patches after strong sun may be scorched.
Identify normal white patterns
Variegated Epipremnum aureum cultivars can have white or cream sectors mixed with green. University of Florida describes Pearls and Jade having white, gray and green blotches and Marble Queen as a white-green form. These colors are genetic leaf traits, not an infection requiring fungicide. Compare multiple healthy leaves and the plant's documented cultivar.

Sun-bleached foliage looks different
Damage often affects the side facing a window or grow light and may begin as pale, bleached areas that become tan, dry or brittle. It can follow a sudden move into stronger afternoon sun. Move to bright filtered light and introduce additional brightness gradually. Dead bleached tissue will not revert to green even after the plant is comfortable.
When pale foliage suggests a broader problem
Uniformly faded or yellowing new leaves with poor growth can reflect low light, damaged roots, nutrient limitation or environmental stress. Check the root zone and overall pattern rather than treating every pale leaf as iron deficiency. Salts and chronic waterlogging can impair nutrient uptake even if fertilizer is present. A properly identified deficiency requires context.

Pest residues and suspicious patches
White powder on a leaf surface may be dust or deposits, mealybug wax, or occasionally a fungal coating; wipe a small area carefully and inspect with good light. Mealybugs tend to form cottony clusters at joints. Powdery deposits are distinct from white pigment inside the leaf. Identify before spraying.
What to do with damaged leaves
Keep leaves with healthy green tissue unless they are severely damaged or part of diagnosed spreading disease. Improve light and root conditions, clean dusty foliage gently and monitor new leaf color. Repeatedly turning the pot into intense sun, scraping leaf surfaces or adding strong fertilizer can worsen the problem.
Frequently asked questions
Is every white leaf diseased?
No; many pothos cultivars are naturally variegated.
Will bleach-white sunburned leaves heal?
No. Prevent further damage and assess new leaves.

